Sepsis is a life-threatening condition in response to dysregulated host response to infection, resulting in cardiovascular compromise and potential multi-organ failure ⁽¹⁾. Macrocirculatory alterations and microcirculation dysfunction are frequent and participate concurrently in the pathophysiology of organ failure. Several studies have described the role of endothelial dysfunction, including damage to the glycocalyx, in the microcirculatory blood flow deterioration in sepsis ⁽²⁾.

Albumin is physiologically bound within the glycocalyx, thus contributing to its stability. Overall, there is growing evidence that albumin may preserve glycocalyx integrity and the microcirculation in the context of acute damage, both in experimental models and in critically ill patients ^(3,4).

(1) Evans L, et al. Intensive Care Med. 2021;47(11):1181-1247.

(2) Uchimido R, et al. Crit Care. 2019;23(1):16.

(3) Aldecoa C, et al. Ann Intensive Care. 2020;10(1):85.

(4) Hariri G, et al. Int Care Med. 2018;44(5):669-671.